Histopathological Changes Due to Interaction of Visceral Larva Migrans and Diabetes Mellitus

The study was aimed to investigate the histopathological changes due to interaction of Visceral Larva Migrans (VLM) and diabetes mellitus in Wistar rats (Rattus norvegicus) and its potential zoonotic risk after being consumed accidently. A total of seventy two adult Wistar rats were taken (N=72) and divided into four groups of 18 rats each viz; group I (healthy control), group II (diabetic control), group III (VLM infected healthy rats) and group IV (VLM infected diabetic rats). Experimental rats exhibited haemorrhages in the liver, lungs and brain on 10, 20 and 30 days post infection (dpi). The accumulation of mononuclear cells in the hepatic parenchyma was observed on 10 dpi. Thrombosis was seen in some blood vessels at 20 dpi. Fibrous connective tissue proliferation in triad areas around the biliary tubules were seen at 30 dpi as compared to control group. Massive hyperplasia of the bronchiolar lymphoid tissue, bronchiolar epithelial and sub-mucosal smooth muscle hyperplasia were seen on 20 and 30 dpi. The brain of rat with diabetes and without diabetes showed the degenerative changes on 10, 20 and 30 dpi.